BD ChloraPrep™ Sterile Solution delivers standardised, powerful, persistent antimicrobial protection that is backed by more than 60 clinical studies and trusted by healthcare providers for more than 21 years. In a recent clinical study, BD ChloraPrep™ Sterile Solution demonstrated antimicrobial persistence for at least 7 days.¹
BD ChloraPrep™ Sterile Solution has a full portfolio of products to meet the coverage area needs of each patient: 3mL, 10.5 mL, and 26 mL sizes.
Skin Prep You Can Trust
The unmatched experience of nearly 5 billion applicators sold in 38 countries for over 21 years with the unparalleled evidence of 60+ clinical studies supporting efficacy and safety.
Sterile Applicator and Solution
Patented sterilisation technology maintains the efficacy and purity of the antiseptic solution
Persistent
Maintaining lower levels of bacteria on the skin while healing is important to minimise bacteria entering the incision site or skin break. In a recent clinical study, BD ChloraPrep™ Sterile Solution demonstrated antimicrobial persistence for at least 7 days.
Standardised Processes and Cost Savings
BD ChloraPrep™ Sterile Solution is the only skin prep that offers a wide range of coverage areas to fit your clinical needs and allows for cost-saving standardised skin prep across care settings.
ChloraPrep™ Sterile Solution is the first antiseptic with a 2% chlorhexidine gluconate (CHG) / 70% isopropyl alcohol (IPA) formulation and provides distinct advantages over other products in how to prepare for surgery.
| Feature | BD ChloraPrep™ Sterile Solution | Other Antiseptics | BD ChloraPrep™ Sterile Solution value |
| Formulation |  |  | Proven broad spectrum, rapid acting antiseptic combination of 2% CHG and 70% IPA with the option for tint. The formulation contains no additional excipients. |
| Available Sizes | | | Vascular and Surgical sizes for consistency in prepping processes. |
| Sterile Applicators with Sterile Solution | | | Less than 1 in a million chance that a viable microorganism can exist in the solution.1 |
| Persistence | | | At least 7 days.2 |
| Studies & Independent Data | | | Supported by more than 60 published peer-reviewed clinical studies. |
| Tint Options | | | Hi-Lite Orange™, Scrub Teal™, and clear for different skin tones. |
| Acting in the presence of organic matter | | | Not neutralized by blood or organic matter.3 |
The BD ChloraPrep™ Sterile Solution formulation uses a combination of chlorhexidine and isopropyl alcohol to provide both rapid killing of bacteria and persistent antimicrobial activity.
IPA rapidly kills microorganisms by denaturing cell proteins, while CHG maintains persistent antimicrobial activity by disrupting the cell membrane and precipitating cell contents. Additionally, CHG is able to bind to the skin and retain antimicrobial activity in the presence of blood and other organic material.
BD ChloraPrep™ Sterile Solution patient preoperative skin preparation delivers standardised, powerful, persistent antimicrobial protection that is backed by more than 60 clinical studies and trusted by healthcare providers for more than 21 years. In a recent clinical study, BD ChloraPrep™ Sterile Solution demonstrated antimicrobial persistence for at least 7 days.¹
“… because the efficacy of any formulation is significantly affected by the excipients present, trials demonstrating activity of one formulation can not be used as evidence for the efficacy of another.”
-Graham W. Denton
Denton G., Chlorhexdine. In: Block S, ed. Disinfection, Sterilisation and Preservation. 5th ed. Lippincott Williams and Wilkins. 2001
BD ChloraPrep™ Sterile Solution meets third party evidence-based standards for preoperative skin antisepsis according to leading healthcare organisations. 4,5,6
Active agents | Traditional iodophors | Alcohol |
|---|---|---|
2016 | World Health Organisation (WHO) 4 | The panel recommends alcohol-based antiseptic solutions based on CHG for surgical skin site preparation. |
2016 | American College of Surgeons and Surgical Infection Society 5 | Alcohol-containing preoperative skin preparatory agents should be used unless contraindication exists. |
2017 | Centers for Disease Control and Prevention(CDC)6 | Perform intraoperative skin preparation withan alcohol-based antiseptic agent unless contraindicated. |
1. Beausoleil C, Comstock SL, Werner D, Li L, Eby JM, Zook EC. Antimicrobial persistence of two alcoholic preoperative skin preparation solutions. J Hosp Infect. 2022 Nov;129:8-16.
2. Hemani ML, Lepor H. Skin preparation for the prevention of surgical site infection: which agent is best? Rev Urol. 2009 Fall;11(4):190-5
3. Denton GW. Chlorhexidine. Disinfection, sterilisation, and preservation. (Edited by S.S. Block, 4th ed) Philadelphia: Lea & Feabiger. 1991. pp. 322–333.
4. Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for Prevention of Surgical Site Infection, 1999. Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee. Am J Infect Control. 1999 Apr;27(2):97-132
5. 2021 AORN Guidelines for Perioperative Practice: Patient Skin Antisepsis
6. WHO 2016 Global guidelines for the prevention of SSIs fact sheet https://cdn.who.int/media/docs/default-source/integrated-health-services-(ihs)/ssi/fact-sheet-skin-web.pdf?sfvrsn=ead06f37_2#:~:text=Surgical%20site%20skin%20preparation%20is,the%20operating%20room%20(OR).
7. Ban KA, Minei JP, Laronga C, Harbrecht BG, Jensen EH, Fry DE, Itani KM, Dellinger EP, Ko CY, Duane TM. American College of Surgeons and Surgical Infection Society: Surgical Site Infection Guidelines, 2016 Update. J Am Coll Surg. 2017 Jan;224(1):59-74
8. Berríos-Torres SI, et al; Healthcare Infection Control Practices Advisory Committee. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017. JAMA Surg. 2017 Aug 1;152(8):784-791.
9. Yokoe DS,,et al; Society for Healthcare Epidemiology of America (SHEA). A compendium of strategies to prevent healthcare-associated infections in acute care hospitals: 2014 updates. Infect Control Hosp Epidemiol. 2014 Aug;35(8):967-77.
10. AORN. Perioperative Standards and Recommended Practices. Denver, CO: AORN, Inc.; 2013:75-89.
11. Galvin P. Am J Nurs. 2009;109(12):49-55. doi: 10.1097/01.NAJ.0000365187.47124.c0.
12. Karpanen TJ, et al. Antimicrob Agents Chemother. 2009;53(4):1717-1719. doi:10.1128/AAC.01289-08.
13. Gilbert, P. and Moore, L.E. (2005), Cationic antiseptics: diversity of action under a common epithet. Journal of Applied Microbiology, 99: 703-715
14. Trautner, B. Skin antisepsis kits containing alcohol and chlorhexidine gluconate, or tincture of iodine are associated with low rates of blood culture contamination. Infection Control and Hospital Epidemiology, 2002.
15. Chen YE, Tsao H. The skin microbiome: current perspectives and future challenges. J Am Acad Dermatol. 2013 Jul;69(1):143-55.
16. Hendley JO, Ashe KM. Antimicrob Agents Chemother 1991 627-31
17. https://www.fda.gov/drugs/drug-safety-and-availability/questions-and-answers-fda-requests-label-changes-and-single-use-packaging-some-over-counter-topical
18. Chang C, Furlong LA. Microbial stowaways in topical antiseptic products. NEngJMed. 2012;367;23:2170-2173. doi: 10.1056/NEJMp1212680.
19. Weber DJ, Rutala WA, Sickbert-Bennett EE. Outbreaks associated with contaminated antiseptics and disinfectants. Antimicrob Agents Chemother. 2007;51(12):4217-4224.
20. Berger SA. Pseudobacteremia due to contaminated alcohol swabs. J Clin Microbiol. 1983;18 (4): 974-975.
21. Edmiston CE Jr, Griggs RK, Tanner J, Spencer M, Seabrook GR, Leaper D. Perioperative hair removal in the 21st century: Utilizing an innovative vacuum-assisted technology to safely expedite hair removal before surgery. Am J Infect Control. 2016 Dec 1;44(12):1639-1644.
22. Redelmeier, DA, Livesley NJ. Adhesive tape and intravascular-catheter-associated infections. J Gen Intern Med. 1999;14(6):373-375
23. AORN. AORN Guidelines for Perioperative Practice. 2015. Retrieved on May 20, 2016 at https://www.aorn.org/guidelines
24. Data on File
25. 2009 WHO Hand Hygiene Guidelines
